Ozone therapy is IV ozone administered in a single injection or by the circulation of blood through a machine. It raises the oxygen levels in your blood to help combat borrelia, an anaerobic bacteria that can’t exist in oxygen-rich situations. (Note: This isn’t true for many Lyme coinfections, which need oxygen to survive.)

Ozone therapy works by creating a high-oxygen environment in the body so that borrelia can’t survive. It may also enhance immune function and reduce inflammation.

Ozone is reasonable to consider, but in my experience, the results are often transient, and many people need additional therapies. Because of the cost and issues with long-term safety, I wouldn’t put this procedure first on my list.

Ozone Therapy — Dr. Rawls’ Summary
Cost: 3 out of 5 dollar signs
Efficacy: 3.5 stars
Safety: 2.5 stars
Ways to Administer: IV, injection, or a pressurized chamber
Bottom Line: Ozone has potential as a Lyme disease treatment, but the results are often short-lived and require further interventions.

Dr. Bill Rawls portraitWant to review more Lyme disease treatments? From antibiotics to herbal therapy, ozone, and more, find out what Dr. Rawls has to say about the efficacy and safety of popular treatments in his Lyme Disease Treatment Guide.

Dr. Rawls is a physician who overcame Lyme disease through natural herbal therapy. You can learn more about Lyme disease in Dr. Rawls’ new best selling book, Unlocking Lyme.
You can also learn about Dr. Rawls’ personal journey in overcoming Lyme disease and fibromyalgia in his popular blog post, My Chronic Lyme Journey.

1. Altinel O, Demirbas S, Cakir E, Yaman H, Ozerhan IH, Duran E, Cayci T, Akgul EO, Ersoz N, Uysal B, Kurt B, Yasar M, Oter S, Peker Y. Comparison of hyperbaric oxygen and medical ozone therapies in a rat model of experimental distal colitis. Scand J Clin Lab Invest. 2011 May;71(3):185-92. doi: 10.3109/00365513.2010