Garlic has been used as a medicinal since the beginning of recorded time, but the active chemicals in garlic, called allicin, are very volatile. The smell of crushed garlic is allicin; it dissipates as soon as the garlic is crushed, cooked, or consumed. Less than 1% is actually absorbed in active form. Therefore, benefit from standard garlic preparations is highly variable and often minimal.
Through a proprietary process, it is possible to stabilize allicin to increase yield to nearly 100%. Stabilized allicin is now available from several companies. Stabilized garlic has been shown to have potent broad-spectrum activity against gram-positive and gram-negative bacteria and has antiviral, antifungal, and antiparasitic properties. Lyme disease patients have noted significant benefit. Studies have shown allicin to be active against multiple species of Babes.
It is highly beneficial for chronic fungal infections and Candida (yeast) and has shown activity against MRSA infections. Stabilized garlic also provides remarkable cardiovascular benefits. It lowers cholesterol, inhibits platelet aggregation (stickiness), improves blood flow, reduces blood pressure, and has direct cardiogenic effects.
Excellent general antimicrobial and for gastrointestinal restoration. Provides antiprotozoal (Babesia) and anti-Candida coverage.
Suggested dosage: 180-1200 mg two stabilized allicin product to three times daily (dosage is dependent on garlic preparation used).
Side effects: well tolerated. Raw garlic can cause stomach upset, but stabilized allicin products are associated with few side effects.
1. Fratianni F, Ricardi R, Spigno P, et al. Biochemical Characterization and Antimicrobial and Antifungal Activity of Two Endemic Varieties of Garlic (Allium sativum L.) of the Campania Region, Southern Italy. J Med Food. 2016;19(7):686-691. Epub 2016 Jun 3.
2. Corral MJ, Benito-Peña E, Jiménez-Antón MD, Cuevas L, Moreno-Bondi MC, Alunda JM. Allicin Induces Calcium and Mitochondrial Dysregulation Causing Necrotic Death in Leishmania. PLoS Negl Trop Dis. 2016;10(3):e0004525.
3. Ranjbar-Omid M, Arzanlou M, Amani M, Shokri Al-Hashem SK, Amir Mozafari N, Peeri Doghaheh H. Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro. FEMS Microbiol Lett. 2015;362(9). Epub 2015 Apr 2.
4. Wu X, Santos RR, Fink-Gremmels J. Analyzing the antibacterial effects of food ingredients: model experiments with allicin and garlic extracts on biofilm formation and viability of Staphylococcus epidermidis. Food Sci Nutr. 2015;3(2):158-168. Epub 2015 Feb 14.
5. Wallock-Richards D, Doherty CJ, Doherty L, et al. Garlic revisited: antimicrobial activity of allicin-containing garlic extracts against Burkholderia cepacia complex. PLoS One. 2014;9(12):e112726.
6. Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID, Slusarenko AJ. Allicin: chemistry and biological properties. Molecules. 2014;19(8):12591-12618.
7. Viswanathan V, Phadatare AG, Mukne A. Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian J Pharm Sci. 2014;76(3):256-261.
8. Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl Hig. 2014;65(1):1-8.
9. Shouk R, Abdou A, Shetty K, Sarkar D, Eid AH. Mechanisms underlying the antihypertensive effects of garlic bioactives. Nutr Res. 2014;34(2):106-115. Epub 2014 Jan 6.
10. Gu X, Wu H, Fu P. Allicin attenuates inflammation and suppresses HLA-B27 protein expression in ankylosing spondylitis mice. Biomed Res Int. 2013;2013:171573.
11. Salama AA, AbouLaila M, Terkawi MA, et al. Inhibitory effect of allicin on the growth of Babesia and Theileria equi parasites. Parasitol Res. 2014;113(1):275-283. Epub 2013 Oct 31.
12. Louis XL, Murphy R, Thandapilly SJ, Yu L, Netticadan T. Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide. BMC Complement Altern Med. 2012;12:140.
13. Chan JY, Pang S, Lin J, Xia J, Wang Y. A review of the cardiovascular benefits and antioxidant properties of allicin. Phytother Res. 2013;27(5):637-646.
14. Feng Y, Zhu X, Wang Q, et al. Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection. Malar J. 2012;11:268.
15. Jiang XW, Zhang Y, Song GD, et al. Clinical evaluation of allicin oral adhesive tablets in the treatment of recurrent aphthous ulceration. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(4):500-504.
16. Li XH, Li CY, Lu JM, Tian RB, Wei J. Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways. Neurosci Lett. 2012;514(1):46-50.
17. Kyung KH. Antimicrobial properties of allium species. Curr Opin Biotechnol. 2012;23(2):142-147.
Rana SV, Pal R, Vaiphei K, Sharma SK, Ola RP. Garlic in health and disease. Nutr Res Rev. 2011;24(1):60-71.
18. Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anticancer Agents Med Chem. 2011;11(3):249-253.
19. Liu C, Cao F, Tang QZ, et al. Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways. J Nutr Biochem. 2010;21(12):1238-1250. Epub 2010 Feb 25.
20. Guo N, Wu X, Yu L, et al. In vitro and in vivo interactions between fluconazole and allicin against clinical isolates of fluconazole-resistant Candida albicans determined by alternative methods. FEMS Immunol Med Microbiol. 2010;58(2):193-201. Epub 2009 Oct 5.
21. Yang LJ, Fan L, Liu ZQ, et al. Effects of allicin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes. Eur J Clin Pharmacol. 2009;65(6):601-608. Epub 2009 Jan 27.
22. Coppi A, Cabinian M, Mirelman D, Sinnis P. Antimalarial activity of allicin, a biologically active compound from garlic cloves. Antimicrob Agents Chemother. 2006;50(5):1731-1737.
23. Gonen A, Harats D, Rabinkov A, et al. The antiatherogenic effect of allicin: possible mode of action. Pathobiology. 2005;72(6):325-334.
24. Lawson LD, Gardner CD. Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem. 2005;53(16):6254-6261.
25. Harris JC, Cottrell SC, Plummer S, Lloyd D. Antimicrobial properties of Allium sativum (garlic). Appl Microbiol Biotechnol. 2001;57(3):282-286.
26. O’Gara EA, Hill DJ, Maslin DJ. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Appl Environ Microbiol. 2000;66(5):2269-2273.
27. McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy. 1993;13(4):406-407.
28. Yoshida S, Kasuga S, Hayashi N, et al. Antifungal activity of ajoene derived from garlic. Appl Environ Microbiol. 1987;53(3):615-617.